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Article

Reductive cleavage of S-adenosylmethionine by biotin synthase from Escherichia coli.

The Journal of biological chemistry - 19 Apr 2002

Ollagnier-de Choudens Sandrine, Sanakis Yiannis, Hewitson Kirsty S, Roach Peter, Münck Eckard, Fontecave Marc

Abstract excerpt

Biotin synthase (BioB) catalyzes the insertion of a sulfur atom between the C6 and C9 carbons of dethiobiotin. Reconstituted BioB from Escherichia coli contains a [4Fe-4S](2+/1+) cluster thought to be involved in the reduction and cleavage of S-adenosylmethionine (AdoMet), generating methionine and the reactive 5'-deoxyadenosyl radical responsible for dethiobiotin H-abstraction. Using EPR and Mössbauer...

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Identifiers

PMID: 11834738
DOI: 10.1074/jbc.M111324200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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