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Article

Iron-sulfur cluster dynamics in biotin synthase: a new [2Fe-2S](1+) cluster.

Biochemical and biophysical research communications - 17 Apr 2009

Lotierzo Manuela, Bui Bernadette Tse Sum, Leech Helen K, Warren Martin J, Marquet Andrée, Rigby Stephen E J

Abstract excerpt

Biotin synthase (BioB) catalyses the final step in the biosynthesis of biotin. Aerobically purified biotin synthase contains one [2Fe-2S](2+) cluster per monomer. However, active BioB contains in addition a [4Fe-4S](2+) cluster which can be formed either by reconstitution with iron and sulfide, or on reduction with sodium dithionite. Here, we use EPR spectroscopy to show that mutations in the conserved YNHNLD...

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Identifiers

PMID: 19245793
DOI: 10.1016/j.bbrc.2009.02.089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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