A simplified method for detecting isoniazid compliance in patients receiving antituberculosis chemotherapy.

doi:10.1177/00912700222011184

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Article

A simplified method for detecting isoniazid compliance in patients receiving antituberculosis chemotherapy.

Journal of clinical pharmacology - 1 Feb 2002

Hashiguchi Masayuki, Ohno Keiko, Sakuma Atsuko, Hino Fumio, Tanaka Takanori, Ohtsuji Masahiko, Matsumoto Naoto, Yanase Kumiko, Urae Akinori, Hosogai Yuki, Sato Naomi, Yazaki Asami, Matsuda Kaoru, Yamazaki Katsuji, Rikihisa Tadaaki

Abstract excerpt

The objective of this study was to develop a new simplified method using thin-layer chromatography (TLC) for determining isoniazid (INH) compliance in patients receiving antituberculosis chemotherapy. TLC was performed on silica gel plates using a standard solution of INH and acetylisoniazid (AcINH) and ethyl acetate-methanol (70:30 v/v) as the developing solvent. The spots of compound were detected by iodine. In...

Topics

Acetylation
Adult
Antitubercular Agents
Arylamine N-Acetyltransferase
Biotransformation
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
DNA
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Isoniazid

Japan

Male

Patient Compliance

Reproducibility of Results

Tuberculosis, Pulmonary

Source

Open in PubMed

Identifiers

PMID: 11831537
DOI: 10.1177/00912700222011184

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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