Article
Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study.
The Journal of rheumatology - 1 Jan 2002
Baldwin Clinton T, Cupples L Adrienne, Joost Oscar, Demissie Serkalem, Chaisson Christine, Mcalindon Timothy, Myers Richard H, Felson David
Abstract excerpt
OBJECTIVE: Studies have suggested that polymorphisms or mutations either in the COL2A1 or VDR gene. both on chromosome 12q, are associated with the occurrence of osteoarthritis (OA). We examined linkage and association between the VDR/COL2A1 locus and hand/knee OA in the Framingham Osteoarthritis Study (FOS). METHODS: Hand and knee joints were characterized radiographically in the FOS. An overall score for OA...
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