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Article

Chromosomal mosaicism throughout human preimplantation development in vitro: incidence, type, and relevance to embryo outcome

1 Feb 2002

Abstract excerpt

BACKGROUND: A large percentage of in-vitro generated cleavage stage human embryos are chromosomally mosaic, consisting of both normal (diploid) and abnormal (non-diploid) cells. The present study characterized mosaicism at each stage of cleavage division and examined its effect on preimplantation development in vitro. METHODS: A total of 216 normally fertilized (two-pronucleate) embryos which were not selected...

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Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics
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Identifiers

PMID: 11821287
DOI: 10.1093/humrep/17.2.413

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