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Article

Detailed FISH analysis of day 5 human embryos reveals the mechanisms leading to mosaic aneuploidy

26 Nov 2004

Abstract excerpt

BACKGROUND: Fluorescence in situ hybridization (FISH) analysis has shown that human embryos display a high level of chromosomal mosaicism at all preimplantation stages. The aim of this study was to investigate the mechanisms involved by the use of two probes for each of three autosomes at different loci and to determine the true level of aneuploid mosaicism by excluding FISH artefacts. METHODS: Embryos were...

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PMID: 15567885
DOI: 10.1093/humrep/deh554

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