Article
Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort.
The Journal of infectious diseases - 1 May 2004
Tozzi Valerio, Zaccarelli Mauro, Narciso Pasquale, Trotta Maria Paola, Ceccherini-Silberstein Francesca, De Longis Patrizio, D'Offizi Giampiero, Forbici Federica, D'Arrigo Roberta, Boumis Evangelo, Bellagamba Rita, Bonfigli Sandro, Carvelli Chiarina, Antinori Andrea, Perno Carlo Federico
Abstract excerpt
BACKGROUND: Hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors (NNRTIs) was described in association with reverse-transcriptase (RT) mutations conferring resistance to nucleoside reverse-transcriptase inhibitors (NRTIs). We evaluated the effect of RT mutations associated with hypersusceptibility to NNRTIs on the response to efavirenz-based therapy. METHODS: We analyzed an observational database...
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