Article
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy.
AIDS (London, England) - 15 Jun 2001
Shulman N, Zolopa A R, Passaro D, Shafer R W, Huang W, Katzenstein D, Israelski D M, Hellmann N, Petropoulos C, Whitcomb J
Abstract excerpt
BACKGROUND: Enhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in association with increased resistance to nucleoside analogs (nucleoside reverse transcriptase inhibitors; NRTI). OBJECTIVES: To determine the prevalence of NNRTI hypersusceptibility, the genotypic correlates, and its impact on virologic response to efavirenz-based salvage therapy. METHODS:...
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