Article
Generation and characterization of a paclitaxel-resistant human gastric carcinoma cell line.
Anti-cancer drugs - 1 Jul 2018
Fu Ling, Yin Fen, Li Xiao-Rui, Han Bing-Kai, Zhang Chuang, Wang Jun-Wei, Wang Yu-Qing, Bi Yue-Feng, Liu Hong-Min
Abstract excerpt
The main aim of this study was to establish a novel paclitaxel (PTX)-resistant human gastric carcinoma cell line and to investigate its biological significance. A cell line, MGC803/PTX, was established by gradually increasing PTX density on the basis of MGC803 over a period of 10 months. In addition, a pair of resistant cell lines (SW620 and SW620/PTX) were added to further explain the resistant mechanism of PTX....
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