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Expression of MDR1 and glutatione S transferase-π genes and chemosensitivities in human gastrointestinal cancer

15 Feb 1992

Abstract excerpt

The relationship was analyzed between drug resistance and MDR1 (with MDR signifying multiple drug resistance) and glutathione S transferase-pi (GST-pi) gene expression in four stomach and four colon cancer cell lines. Northern blot analysis by pmdr1 probe showed that stomach cancer cell lines had no detectable level of MDR1 mRNA expression. By contrast, some levels of MDR1 mRNA expression were found in two colon...

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PMID: 1735085
DOI: 10.1002/1097-0142(19920215)69:4<941::aid-cncr2820690418>3.0.co;2-h

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