Article
Parthenin, a sesquiterpene lactone of Parthenium hysterophorus L. is a high toxicity clastogen.
Mutation research - 15 Feb 2002
Ramos Alberto, Rivero Reinaldo, Visozo Angel, Piloto Janet, García Arilia
Abstract excerpt
The in vitro and in vivo genotoxicity of parthenin, a sesquiterpene lactone from Parthenium hysterophorus L. with allergenic and irritant action, was assessed in three short-term tests: bacterial reversion in Salmonella typhimurium and Escherichia coli, in vitro chromosomal aberrations in peripheral blood lymphocytes and micronuclei in mouse peripheral blood. Parthenin was not mutagenic in S. typhimurium strains...
Topics
- Allergens
- Animals
- Chromosome Aberrations
- Escherichia coli
- Female
- Lymphocytes
- Male
- Mice
- Micronuclei, Chromosome-Defective
- Micronucleus Tests
- Molecular Structure
- Mutagenicity Tests
- Mutagens
- Mutation
- Salmonella typhimurium
- Sesquiterpenes
- Uncoupling Agents