Article
In vitro and in vivo mutagenicity studies on sporidesmin, the toxin associated with facial eczema in ruminants.
Mutation research - 1 Aug 1992
Ferguson L R, Berriman J, Pearson A, Munday R, Fowke E A, Towers N R
Abstract excerpt
Sporidesmin, a fungal toxin with widespread distribution within New Zealand, is thought to exert toxic effects through oxidative damage. The purified chemical was tested for its ability to cause point mutations in four strains of Salmonella typhimurium (TA98, TA100, TA102 and TA1537), in the presence and absence of exogenous metabolic activation. Although toxic effects were seen at concentrations exceeding 400 mu...
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