Article
Use of inverse PCR to amplify and sequence breakpoints of HPRT deletion and translocation mutations.
Environmental and molecular mutagenesis - 1 Jan 2002
Williams M, Rainville I R, Nicklas J A
Abstract excerpt
Deletion and translocation mutations have been shown to play a significant role in the genesis of many cancers. The hprt gene located at Xq26 is a frequently used marker gene in human mutational studies. In an attempt to better understand potential mutational mechanisms involved in deletions and translocations, inverse PCR (IPCR) methods to amplify and sequence the breakpoints of hprt mutants classified as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.