Distinction between IL-13+ and IFN-gamma+ natural killer cells and regulation of their pool size by IL-4.

Abstract excerpt

The hypothesis that distinct subsets of NK cells produce type 2 and type 1 cytokines in resting naive lymphocytes was tested analyzing cytokine production at the single-cell level. Two non-overlapping IL-13+ and IFN-gamma+ subsets were identified in adult and neonatal NK cells. IL-2 maintained their relative proportion. Accumulation of the former was induced by IL-4, but not IL-13, and inhibited by IL-12; that of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Calcimycin
• Share to Interferon-gamma
• Share to Interleukin-13