Article
A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo.
Blood - 15 May 2008
Guia Sophie, Cognet Céline, de Beaucoudrey Ludovic, Tessmer Marlowe S, Jouanguy Emmanuelle, Berger Claire, Filipe-Santos Orchidée, Feinberg Jacqueline, Camcioglu Yildiz, Levy Jacob, Al Jumaah Suliman, Al-Hajjar Sami, Stephan Jean-Louis, Fieschi Claire, Abel Laurent, Brossay Laurent, Casanova Jean-Laurent, Vivier Eric
Abstract excerpt
Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon-gamma (IFN-gamma) and for their cytotoxic response. In patients with IL12RB1 mutations that lead to a complete IL-12Rbeta1 deficiency, the size of this...
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