Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-12 receptor. II. Distribution and regulation of receptor expression.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1992

Desai B B, Quinn P M, Wolitzky A G, Mongini P K, Chizzonite R, Gately M K

Abstract excerpt

IL-12 is a heterodimeric lymphokine that induces IFN-gamma production by resting PBMC, enhances the lytic activity of NK/lymphokine activated killer cells, and causes the proliferation of activated T cells and NK cells. In this report, we have investigated the expression of IL-12R on mitogen- and IL-2-activated PBMC or tonsillar lymphocytes as well as on a variety of cell lines. The results of radiolabeled...

Topics

Animals
CD4 Antigens
CD8 Antigens
Calcimycin
Cell Line
Cells, Cultured
Humans
Interleukin-2
Lymphocyte Activation
Lymphocytes
Phenotype
Phytohemagglutinins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Interleukin-2

Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 1578139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1578139-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-12 receptor. II. Distribution and regulation of receptor expression.PMID 1578139Read ↗

In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitmentSemantic proximity Read ↗

Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.Semantic proximity Read ↗

Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity.Semantic proximity Read ↗

Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathwaySemantic proximity Read ↗

Expression cloning and characterization of a human IL-10 receptor.Semantic proximity Read ↗

Absence of IL-6 receptor expression in fresh childhood Burkitt's lymphoma cells and induction of IL-6 receptors by Epstein-Barr virus in vitro.Semantic proximity Read ↗

Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (TAC) negative phenotype.Semantic proximity Read ↗

T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation.Semantic proximity Read ↗

Binding of interleukin-13 and interleukin-4 to the interleukin (IL)-4/IL-13 receptor of human synovial fibroblasts.Semantic proximity Read ↗

Distinction between IL-13+ and IFN-gamma+ natural killer cells and regulation of their pool size by IL-4.Semantic proximity Read ↗

IL-2 Receptor Blockade Inhibits Late, But Not Early, IFN-γ and CD40 Ligand Expression in Human T Cells: Disruption of Both IL-12-Dependent and -Independent Pathways of IFN-γ ProductionSemantic proximity Read ↗

Interleukin‐dependent modulation of HLA‐DR expression on CD4 and CD8 activated T cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.