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Article

Ablation of Drosophila photoreceptor cells by conditional expression of a toxin gene.

Genes & development - 1 Jun 1991

Kunes S, Steller H

Abstract excerpt

We have used toxin-mediated ablation to study some aspects of visual system development in Drosophila melanogaster. To devise a method that permits the conditional expression of a cellular toxin, we introduced an amber mutation into the diphtheria toxin-A-chain gene. In transgenic animals, this toxin gene can be activated by providing the gene for an amber suppressor tRNA. By coupling this toxin gene to the...

Topics

Animals
Base Sequence
Cell Differentiation
DNA
Diphtheria Toxin
Drosophila
Eye
Gene Expression
Germ Cells
Immunohistochemistry
Molecular Sequence Data
Optic Nerve

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Photoreceptor Cells

Transformation, Genetic

Source

Identifiers

PMID: 2044963
DOI: 10.1101/gad.5.6.970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2044963-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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