Molecular Evidence of Endogenous Reactivation of<i>Mycobacterium tuberculosis</i>after 33 Years of Latent Infection

Abstract excerpt

Since Robert Koch described the cause of tuberculosis in 1882, the natural history of the disease after primary infection has been subject to debate. Only approximately 10% of infected individuals develop active disease, which may appear years to decades after infection. Late onset has been attributed to the endogenous reactivation of dormant bacteria. However, this has not been documented by molecular means for...

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