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Animal models of Huntington’s disease and their applicability to novel drug discovery and development

11 Apr 2023

Abstract excerpt

INTRODUCTION: Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The discovery of the HD-causing gene prompted the creation of new HD animal models, proving that mutations in the HD gene are linked to either loss of function of the wild-type (un-mutated) gene or toxic gain in the function of a mutated gene. AREAS...

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PMID: 37042034
DOI: 10.1080/17460441.2023.2201493

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