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Article

CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19.

European journal of immunology - 1 May 2010

Britschgi Mirjam R, Favre Stéphanie, Luther Sanjiv A

Abstract excerpt

Mice deficient in CCR7 signals show severe defects in lymphoid tissue architecture and immune response. These defects are due to impaired attraction of CCR7+ DC and CCR7+ T cells into the T zones of secondary lymphoid organs and altered DC maturation. It is currently unclear which CCR7 ligand mediates these processes in vivo as CCL19 and CCL21 show an overlapping expression pattern and blocking experiments have...

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Source

Identifiers

PMID: 20201039
DOI: 10.1002/eji.200939921

Genes

CCL19
CCL21
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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