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Article

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice.

The Journal of biological chemistry - 18 Jul 2008

Wen Yuhui, Pinto Jose Renato, Gomes Aldrin V, Xu Yuanyuan, Wang Yingcai, Wang Ying, Potter James D, Kerrick W Glenn L

Abstract excerpt

In this study, we addressed the functional consequences of the human cardiac troponin I (hcTnI) hypertrophic cardiomyopathy R145G mutation in transgenic mice. Simultaneous measurements of ATPase activity and force in skinned papillary fibers from hcTnI R145G transgenic mice (Tg-R145G) versus hcTnI wild type transgenic mice (Tg-WT) showed a significant decrease in the maximal Ca(2+)-activated force without changes...

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Identifiers

PMID: 18430738
DOI: 10.1074/jbc.M801661200
PMCID: PMC2459290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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