Article
Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.
Science (New York, N.Y.) - 18 Jan 2002
Takasu Mari A, Dalva Matthew B, Zigmond Richard E, Greenberg Michael E
Abstract excerpt
Protein-protein interactions and calcium entry through the N-methyl-d-aspartate (NMDA)-type glutamate receptor regulate synaptic development and plasticity in the central nervous system. The EphB receptor tyrosine kinases are localized at excitatory synapses where they cluster and associate with NMDA receptors. We identified a mechanism whereby EphBs modulate NMDA receptor function. EphrinB2 activation of EphB in...
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