Article
Ap-2 and Ikaros regulate transcription of human placental leucine aminopeptidase/oxytocinase gene.
Biochemical and biophysical research communications - 25 Jan 2002
Ito Tomomi, Nomura Seiji, Okada Mayumi, Katsumata Yoshinari, Kikkawa Fumitaka, Rogi Tomohiro, Tsujimoto Masafumi, Mizutani Shigehiko
Abstract excerpt
P-LAP is identical with cystine aminopeptidase as oxytocinase. We previously located on the placental leucine aminopeptidase (P-LAP) gene the footprint site with the high promoter activity (FP3: -214 to -183) and found a possible interaction between it and AP-2 in choriocarcinoma cells. Here, we investigated FP3 in detail and identified the elements responsible for the high basal rate of transcription....
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