Article
The use of sequential designs in genome scans for asthma susceptibility loci with affected sib pairs.
Genetic epidemiology - 1 Jan 2001
Böddeker I R, Müller H H, Kress R, Geller F, Ziegler A, Schäfer H
Abstract excerpt
We use optimized group sequential study designs to analyze data from two genome scans (German and CSGA) for asthma susceptibility loci with affected sib pairs from Genetic Analysis Workshop (GAW) 12. Results are compared with those from a fixed sample design and the sequential probability ratio test (SPRT). The SPRT does not reach significance at any position. Using the fixed sample design, evidence for linkage...
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