Article
Detecting population outliers and null alleles in linkage data: application to GAW12 asthma studies.
Genetic epidemiology - 1 Jan 2001
Fisher S A, Lewis C M, Wise L H
Abstract excerpt
Error-checking procedures are essential to ensure accurate and powerful linkage analysis. Genotype information across families can be used to identify non-amplification of alleles (null alleles) and between-family population sub-structuring, which can result in loss of power in linkage studies if undetected. Methods to identify population outlier individuals and null alleles are applied to genotype data from two...
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