Article
Influence of marker heterozygosity and genetic heterogeneity on fine mapping.
Genetic epidemiology - 1 Jan 2001
Heard-Costa N L, Demissie S, DeStefano A L, Knowlton B A, Maher N E, Myers R H, Volcjak J S, Wilk J B, Cupples L A
Abstract excerpt
The purpose of the current study was to utilize the Genetic Analysis Workshop 12 simulated data to evaluate fine-mapping strategies for quantitative traits. We approached the analysis as if it was a follow-up to a genome scan that had identified two regions of interest and used the provided 1-cM density microsatellite typing data to mimic fine mapping of these regions. As these investigators knew the true...
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