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Article

The limits of fine-scale mapping.

Genetic epidemiology - 1 May 2009

Smith Lucian P, Kuhner Mary K

Abstract excerpt

When a novel genetic trait arises in a population, it introduces a signal in the haplotype distribution of that population. Through recombination that signal's history becomes differentiated from the DNA distant to it, but remains similar to the DNA close by. Fine-scale mapping techniques rely on this differentiation to pinpoint trait loci. In this study, we analyzed the differentiation itself to better...

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Identifiers

PMID: 19048633
DOI: 10.1002/gepi.20387
PMCID: PMC2707455

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