Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2002

Shirangi Troy R, Zaika Alex, Moll Ute M

Abstract excerpt

The principal regulator of p53 stability is HDM2, an E3 ligase that mediates p53 degradation via the ubiquitin-26S proteasome pathway. The current model holds that p53 degradation occurs exclusively on cytoplasmic proteasomes and hence has an absolute requirement for nuclear export of p53 via the CRM-1 pathway. However, proteasomes are abundant in both cytosol and nucleus, and no studies have been done to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to DNA Damage

Share to Down-Regulation

Share to Nuclear Localization Signals

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-mdm2

Source

Identifiers

PMID: 11790725
DOI: 10.1096/fj.01-0617fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage.PMID 11790725Read ↗

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6Semantic proximity Read ↗

C-terminal ubiquitination of p53 contributes to nuclear export.Semantic proximity Read ↗

Cytoplasmic Translocation of p53 by Human Cytomegalovirus InfectionSemantic proximity Read ↗

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities.Semantic proximity Read ↗

Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.Semantic proximity Read ↗

c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and UbiquitinationSemantic proximity Read ↗

Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2.Semantic proximity Read ↗

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.Semantic proximity Read ↗

Checkpoint-dependent RNR induction promotes fork restart after replicative stress.Semantic proximity Read ↗

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.Semantic proximity Read ↗

Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus.Semantic proximity Read ↗

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.