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Article

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1 Dec 1998

Abstract excerpt

The MDM2 oncoprotein targets the p53 tumor suppressor protein for degradation when the two proteins are expressed in cells. The regulation of p53 levels by MDM2 requires the ability of MDM2 to be exported from the nucleus by utilizing its nuclear export signal (NES). The drug leptomycin B (LMB) blocks the formation of nuclear export complexes consisting of CRM1, RanGTP, and NES-containing proteins. It is...

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PMID: 9819415
DOI: 10.1128/mcb.18.12.7288

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Related research

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Research trail→

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Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6PMID 9819415Read ↗

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