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Article

Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.

The Journal of biological chemistry - 23 Jun 2006

Oh Wonkyung, Lee Eun-Woo, Sung Young Hoon, Yang Mi-Ran, Ghim Jaewang, Lee Han-Woong, Song Jaewhan

Abstract excerpt

The biological mechanisms for maintaining the basal level of p53 in normal cells require nuclear exclusion and cytoplasmic degradation. Here, we showed that Jab1 facilitates p53 nuclear exclusion and its subsequent degradation in coordination with Hdm2. p53 was excluded from the nucleus in the presence of Jab1; this exclusion was prevented by leptomycin B treatment. Nuclear export of p53 was accompanied by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intracellular Signaling Peptides and Proteins

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 16624822
DOI: 10.1074/jbc.M601857200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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