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Article

Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2.

Molecular pharmaceutics - 1 Apr 2013

Davis James R, Mossalam Mohanad, Lim Carol S

Abstract excerpt

The tumor suppressor p53 can be sent to the proteasome for degradation by placing its nucleo-cytoplasmic shuttling under ligand control. Endogenous p53 is ubiquitinated by MDM2 in the nucleus, and controlling the access of p53 to the nuclear compartment regulates its ubiquitination and proteasomal degradation. This was accomplished by the use of a protein switch that places nuclear translocation under the control...

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Source

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Identifiers

PMID: 23398638
DOI: 10.1021/mp300543t
PMCID: PMC3658471

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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