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Article

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

Science (New York, N.Y.) - 12 Dec 2003

Li Muyang, Brooks Christopher L, Wu-Baer Foon, Chen Delin, Baer Richard, Gu Wei

Abstract excerpt

Although Mdm2-mediated ubiquitination is essential for both degradation and nuclear export of p53, the molecular basis for the differential effects of Mdm2 remains unknown. Here we show that low levels of Mdm2 activity induce monoubiquitination and nuclear export of p53, whereas high levels promo...

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Identifiers

PMID: 14671306
DOI: 10.1126/science.1091362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14671306-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.PMID 14671306Read ↗

MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding.Semantic proximity Read ↗

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.Semantic proximity Read ↗

Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.Semantic proximity Read ↗

C-terminal ubiquitination of p53 contributes to nuclear export.Semantic proximity Read ↗

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.Semantic proximity Read ↗

The p53 isoforms are differentially modified by Mdm2Semantic proximity Read ↗

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.Semantic proximity Read ↗

Regulation of p53 stability by Mdm2.Semantic proximity Read ↗

Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.Semantic proximity Read ↗

Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.Semantic proximity Read ↗

Ubiquitination of p53 at multiple sites in the DNA-binding domain.Semantic proximity Read ↗

Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.Semantic proximity Read ↗

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