Article
Inhibition of Poly(ADP-ribose) Polymerase Activity by Bcl-2 in Association with the Ribosomal Protein S3a
22 Dec 2001
Abstract excerpt
We screened a human lymphocyte cDNA library using the yeast two-hybrid system and an automodification domain of PARP as a probe. The DNA sequence of an isolated clone (clone 3-9) was identical to the partial cDNA sequence of the human ribosomal protein S3a. We confirmed that PARP interacts with clone 3-9 by performing binding studies using a GST-3-9 fusion protein as bait. We also demonstrated that native S3a in...
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