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Article

How to kill tumor cells with inhibitors of poly(ADP‐ribosyl)ation

17 Sept 2010

Abstract excerpt

Poly(ADP-ribosyl)ation is a post-translational modification catalyzed by the enzyme family of poly(ADP-ribose) polymerases (PARPs). PARPs exhibit pleiotropic cellular functions ranging from maintenance of genomic stability and chromatin remodeling to regulation of cell death, thereby rendering PARP homologues promising targets in cancer therapy. Depending on the molecular status of a cancer cell, low-molecular...

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PMID: 20853319
DOI: 10.1002/ijc.25683

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