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Modulation of radiation response by inhibiting topoisomerase II catalytic activity.

Mutation research - 25 Jul 2006

Mateos Santiago, Hajji Nabil, Pastor Nuria, Cortés Felipe

Abstract excerpt

Due to the essential role played by DNA topoisomerases (topos) in cell survival, the use of topoisomerase inhibitors as chemotherapeutic drugs in combination with radiation has become a common strategy for the treatment of cancer. Catalytic inhibitors of these enzymes would be promising to improve the effectiveness of radiation and therefore, it appears reasonable to incorporate them in combined modality trials....

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Identifiers

PMID: 16574164
DOI: 10.1016/j.mrfmmm.2006.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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