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Article

Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain.

Nature structural biology - 1 Aug 1998

Grantcharova V P, Riddle D S, Santiago J V, Baker D

Abstract excerpt

Experimental and theoretical studies on the folding of small proteins such as the chymotrypsin inhibitor 2 (CI-2) and the P22 Arc repressor suggest that the folding transition state is an expanded version of the native state with most interactions partially formed. Here we report that this picture does not hold generally: a hydrogen bond network involving two beta-turns and an adjacent hydrophobic cluster appear...

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Identifiers

PMID: 9699636
DOI: 10.1038/1412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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