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Article

The relationship between conservation, thermodynamic stability, and function in the SH3 domain hydrophobic core.

Journal of molecular biology - 24 Oct 2003

Di Nardo Ariel A, Larson Stefan M, Davidson Alan R

Abstract excerpt

To investigate the relationships between sequence conservation, protein stability, and protein function, we have measured the thermodynamic stability, folding kinetics, and in vitro peptide-binding activity of a large number of single-site substitutions in the hydrophobic core of the Fyn SH3 domain. Comparison of these data to that derived from an analysis of a large alignment of SH3 domain sequences revealed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14556750
DOI: 10.1016/j.jmb.2003.08.035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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