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Article

Structurally normal corneas in aldehyde dehydrogenase 3a1-deficient mice.

Molecular and cellular biology - 1 Feb 2002

Nees David W, Wawrousek Eric F, Robison W Gerald, Piatigorsky Joram

Abstract excerpt

We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wild-type mice, and contain no ALDH3a1 as determined by zymograms and immunoblots. Despite the loss...

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Identifiers

PMID: 11784860
DOI: 10.1128/MCB.22.3.849-855.2002
PMCID: PMC133561

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