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Article

Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.

Scientific reports - 3 Jun 2020

Sunny Sweetu Susan, Lachova Jitka, Dupacova Naoko, Zitova Anna, Kozmik Zbynek

Abstract excerpt

Conditional gene targeting in mice by means of Cre-loxP strategy represents a powerful approach to study mammalian gene function. This approach is however dependent on the availability of suitable strains of mice with a tissue or time restricted activity of the Cre recombinase. Here we describe Aldh3-Cre transgenic mice as a useful tool to conditionally delete genes in cornea, a specialized transparent tissue...

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Identifiers

PMID: 32493941
DOI: 10.1038/s41598-020-65878-1
PMCID: PMC7270111

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