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Article

The prevalence of "pure" autosomal dominant hereditary spastic paraparesis in the island of Ireland

1 Jan 2002

Abstract excerpt

OBJECTIVES: Hereditary spastic paraparesis (HSP) is clinically and genetically heterogeneous. "Pure" autosomal dominant (AD) HSP is most common and eight genetic loci are identified to date. Previous studies have included autosomal recessive and sporadic cases in prevalence calculations. This study aimed to determine the prevalence and features of pure ADHSP in the island of Ireland. METHODS: Index cases were...

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PMID: 11784824
DOI: 10.1136/jnnp.72.1.43

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