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Article

Clinical heterogeneity of autosomal recessive spastic paraplegias: analysis of 106 patients in 46 families.

Archives of neurology - 1 Aug 1999

Coutinho P, Barros J, Zemmouri R, Guimarães J, Alves C, Chorão R, Lourenço E, Ribeiro P, Loureiro J L, Santos J V, Hamri A, Paternotte C, Hazan J, Silva M C, Prud'homme J F, Grid D

Abstract excerpt

BACKGROUND: Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurodegenerative disorders characterized by progressive and predominant spasticity of the lower limbs, in which dominant, recessive, and X-linked forms have been described. While autosomal dominant HSP has been extensively studied, autosomal recessive HSP is less well known and is considered a rare condition. OBJECTIVE: To analyze the...

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PMID: 10448799
DOI: 10.1001/archneur.56.8.943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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