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Article

An integrated modelling methodology for estimating global incidence and prevalence of hereditary spastic paraplegia subtypes SPG4, SPG7, SPG11, and SPG15.

BMC neurology - 24 Mar 2022

Vander Stichele Geert, Durr Alexandra, Yoon Grace, Schüle Rebecca, Blackstone Craig, Esposito Giovanni, Buffel Connor, Oliveira Inês, Freitag Christian, van Rooijen Stephane, Hoffmann Stéphanie, Thielemans Leen, Cowling Belinda S

Abstract excerpt

BACKGROUND: Hereditary spastic paraplegias (HSPs) are progressively debilitating neurodegenerative disorders that follow heterogenous patterns of Mendelian inheritance. Available epidemiological evidence provides limited incidence and prevalence data, especially at the genetic subtype level, preventing a realistic estimation of the true social burden of the disease. The objectives of this study were to (1) review...

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Identifiers

PMID: 35331153
DOI: 10.1186/s12883-022-02595-4
PMCID: PMC8944001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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