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Article

Conditional ablation of cerebellar astrocytes in postnatal transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 1996

Delaney C L, Brenner M, Messing A

Abstract excerpt

Astrocytes have been proposed to have multiple roles in the development and maintenance of the vertebrate CNS. To facilitate documentation of these roles, we designed a transgene to enable their ablation at selectable times. The transgene consists of the coding region for the herpes simplex virus-thymidine kinase (HSV-TK) under the control of the human glial fibrillary acidic protein gene promoter. The HSV-TK is...

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Identifiers

PMID: 8824329
PMCID: PMC6579279

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