Conditional ablation of cerebellar astrocytes in postnatal transgenic mice.

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Article

Conditional ablation of cerebellar astrocytes in postnatal transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 1996

Delaney C L, Brenner M, Messing A

Abstract excerpt

Astrocytes have been proposed to have multiple roles in the development and maintenance of the vertebrate CNS. To facilitate documentation of these roles, we designed a transgene to enable their ablation at selectable times. The transgene consists of the coding region for the herpes simplex virus...

Topics

Animals
Animals, Newborn
Astrocytes
Ataxia
Cell Count
Cell Death
Cell Survival
Cerebellum
Female
Ganciclovir
Glial Fibrillary Acidic Protein
In Situ Hybridization
Mice
Mice, Transgenic
Neurotoxins
Phenotype
Pregnancy
Receptors, N-Methyl-D-Aspartate

Source

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Identifiers

PMID: 8824329
PMCID: PMC6579279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8824329-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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