Article
Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation.
Journal of neuroscience research - 15 Jan 2002
Getchell Thomas V, Shah Dharmen S, Partin James V, Subhedar Nishikant K, Getchell Marilyn L
Abstract excerpt
After target ablation by olfactory bulbectomy (OBX), the murine olfactory epithelium (OE) undergoes degenerative changes leading to apoptosis of olfactory receptor neurons (ORNs) followed by regenerative changes that include proliferation of progenitor cells leading to neurogenesis and ORN replacement. Macrophages recruited to the OE after OBX are involved in both the degenerative and regenerative processes....
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