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Article

Leukemia inhibitory factor deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2008

Linker Ralf A, Kruse Niels, Israel Stephanie, Wei Tao, Seubert Silvia, Hombach Anja, Holtmann Bettina, Luhder Fred, Ransohoff Richard M, Sendtner Michael, Gold Ralf

Abstract excerpt

The neurotrophic cytokines ciliary neurotrophic factor and leukemia inhibitory factor (LIF) play a key role in neuronal and oligodendrocyte survival and as protective factors in neuroinflammation. To further elucidate the potential of endogenous LIF in modulating neuroinflammation, we studied myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in LIF knockout mice (LIF(-/-)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Encephalomyelitis, Autoimmune, Experimental

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Source

Identifiers

PMID: 18250427
DOI: 10.4049/jimmunol.180.4.2204

Genes

LIF
CCL2
CCL3
CXCL1
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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