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SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection

2 Apr 2003

Abstract excerpt

Precise analysis of human CD34-negative (CD34(-)) hematopoietic stem cells (HSCs) has been hindered by the lack of a simple and reliable assay system of these rare cells. Here, we successfully identify human cord blood-derived CD34(-) severe combined immunodeficiency (SCID)- repopulating cells (SRCs) with extensive lymphoid and myeloid repopulating ability using the intra-bone marrow injection (IBMI) technique....

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PMID: 12480697
DOI: 10.1182/blood-2002-09-2782

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