Article
PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites.
Oncogene - 13 Dec 2001
Santilli G, Cervellera M N, Johnson T K, Lewis R E, Iacobelli S, Sala A
Abstract excerpt
PARP is a multifunctional protein that can affect genome stability, transcription control, telomere length and cell death. Recently we have reported that PARP binds to and enhances B-MYB transactivating potential. B-MYB is a potentially oncogenic transcription factor involved in mammalian cell proliferation, survival and differentiation. B-MYB gene expression is growth regulated and B-MYB protein is...
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