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Article

Activation of human B-MYB by cyclins

21 Jan 1997

Abstract excerpt

B-MYB expression is associated with cell proliferation and recent studies have suggested that it promotes the S phase of mammalian cells. Based on its homology to the transcription factors c-MYB and A-MYB, B-MYB is thought to be involved in transcriptional regulation; however, its activity is not detectable in several cell lines. It was postulated that B-MYB function may depend on the presence of a cofactor, and...

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Identifiers

PMID: 9012818
DOI: 10.1073/pnas.94.2.532

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Activation of human B-MYB by cyclinsPMID 9012818Read ↗

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Mitotic cyclins stimulate the activity of c-Myb-like factors for transactivation of G2/M phase-specific genes in tobacco.Semantic proximity Read ↗

MYB and MYC in the cell cycle.Semantic proximity Read ↗

E2F binding is required but not sufficient for repression of B-myb transcription in quiescent fibroblasts.Semantic proximity Read ↗

The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.Semantic proximity Read ↗

E2Fs link the control of G1/S and G2/M transcription.Semantic proximity Read ↗

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.Semantic proximity Read ↗

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