Article
Regulation of the cyclin D1 and cyclin A1 promoters by B-Myb is mediated by Sp1 binding sites.
Gene - 23 May 2005
Bartusel Thorsten, Schubert Stephan, Klempnauer Karl-Heinz
Abstract excerpt
B-Myb is a highly conserved member of the Myb family of transcription factors which plays an important role during the cell cycle. Previous work has shown that B-Myb is phosphorylated at several sites by cyclin A/Cdk2 in the early S-phase. These phosphorylations increase the transactivation potential of B-Myb by counteracting the repressive function of an inhibitory domain located at the carboxyl-terminus of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
