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Estimating the scaled mutation rate and mutation bias with site frequency data.

Theoretical population biology - 1 Dec 2014

Vogl Claus

Abstract excerpt

The distribution of allele frequencies of a large number of biallelic sites is known as "allele-frequency spectrum" or "site-frequency spectrum" (SFS). Without selection and in regions of relatively high recombination rates, sites may be assumed to be independently and identically distributed. With a beta equilibrium distribution of allelic proportions and binomial sampling, a beta-binomial compound likelihood...

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PMID: 25453604
DOI: 10.1016/j.tpb.2014.10.002

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